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Effect of Calcium-sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems
The calcium dependent interactions between troponin C (TnC) and other thin and thick filament proteins play a key role in regulation of cardiac muscle contraction. Five hydrophobic residues Phe(20), Val(44), Met(45), Leu(48) and Met(81) in the regulatory domain of TnC were individually substituted w...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845643/ https://ncbi.nlm.nih.gov/pubmed/20128626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901867s |
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