Effect of Calcium-sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

The calcium dependent interactions between troponin C (TnC) and other thin and thick filament proteins play a key role in regulation of cardiac muscle contraction. Five hydrophobic residues Phe(20), Val(44), Met(45), Leu(48) and Met(81) in the regulatory domain of TnC were individually substituted w...

Full description

Saved in:
Bibliographic Details
Main Authors: Tikunova, Svetlana B., Liu, Bin, Swindle, Nicholas, Little, Sean C., Gomes, Aldrin V., Swartz, Darl R., Davis, Jonathan P.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845643/
https://ncbi.nlm.nih.gov/pubmed/20128626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901867s
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items