On the Role of Topoisomerase I in Mediating the Cytotoxicity of 9-Aminoacridine-Based Anticancer Agents

The cytotoxicity and mechanism of action of a series of substituted 9-aminoacridines is evaluated using topoisomerase I and cancer cell growth inhibition assays. In previous work, compounds of this type were shown to catalytically inhibit topoisomerase II, leading to a G1-S phase arrest of the cell...

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Bibliographic Details
Main Authors: Gálvez-Peralta, Marina, Hackbarth, Jennifer S., Flatten, Karen S., Kaufmann, Scott H., Hiasa, Hiroshi, Xing, Chenguo, Ferguson, David M.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845530/
https://ncbi.nlm.nih.gov/pubmed/19501511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.037
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