Dissection of platelet and myeloid cell defects by conditional targeting of the β3-integrin subunit

The purpose of this work was to determine platelet and myeloid cell-specific requirements for β3-containing integrins in hemostasis, bone resorption, and tumor growth. LoxP-flanked mice were generated to study the conditional deletion of β3-integrin in platelets [knockout in platelets (KOP)] and mye...

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Autors principals: Morgan, Elizabeth A., Schneider, Jochen G., Baroni, Timothy E., Uluçkan, Özge, Heller, Emanuela, Hurchla, Michelle A., Deng, Hongju, Floyd, Desiree, Berdy, Andrew, Prior, Julie L., Piwnica-Worms, David, Teitelbaum, Steven L., Ross, F. Patrick, Weilbaecher, Katherine N.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2010
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845430/
https://ncbi.nlm.nih.gov/pubmed/19933310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-138420
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