Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment

Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we demonstrate that inhibition of Hh pathway activity inhibits tumor growth through effects on the microenvironment. Pharmacological inhibition of the Hh effector Smoothened (Smo) increased trabecular bone in...

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Detalhes bibliográficos
Main Authors: Heller, Emanuela, Hurchla, Michelle A., Xiang, Jingyu, Chen, Sara, Schneider, Jochen, Joeng, Kyu-Sang, Vidal, Marcos, Goldberg, Leah, Deng, Hongju, Hornick, Mary C., Prior, Julie L., Piwnica-Worms, David, Long, Fanxin, Cagan, Ross, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659806/
https://ncbi.nlm.nih.gov/pubmed/22186138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2681
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