Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment

Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we demonstrate that inhibition of Hh pathway activity inhibits tumor growth through effects on the microenvironment. Pharmacological inhibition of the Hh effector Smoothened (Smo) increased trabecular bone in...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Heller, Emanuela, Hurchla, Michelle A., Xiang, Jingyu, Chen, Sara, Schneider, Jochen, Joeng, Kyu-Sang, Vidal, Marcos, Goldberg, Leah, Deng, Hongju, Hornick, Mary C., Prior, Julie L., Piwnica-Worms, David, Long, Fanxin, Cagan, Ross, Weilbaecher, Katherine N.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659806/
https://ncbi.nlm.nih.gov/pubmed/22186138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2681
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items