DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

BACKGROUND: When DNA double-strand breaks (DSB) are induced by ionizing radiation (IR) in cells, histone H2AX is quickly phosphorylated into γ-H2AX (p-S139) around the DSB site. The necessity of DNA-PKcs in regulating the phosphorylation of H2AX in response to DNA damage and cell cycle progression w...

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Main Authors: An, Jing, Huang, Yue-Cheng, Xu, Qing-Zhi, Zhou, Li-Jun, Shang, Zeng-Fu, Huang, Bo, Wang, Yu, Liu, Xiao-Dan, Wu, De-Chang, Zhou, Ping-Kun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844398/
https://ncbi.nlm.nih.gov/pubmed/20205745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-18
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