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Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy

Cancer stem cells represent a novel therapeutic target. The major challenge in targeting leukemic stem cells (LSCs) is finding therapies that largely spare normal hematopoietic stems cells (HSCs) while eradicating quiescent LSCs. We present a mathematical model to predict how selective a therapy mus...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sehl, Mary E., Sinsheimer, Janet S., Zhou, Hua, Lange, Kenneth L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844253/
https://ncbi.nlm.nih.gov/pubmed/19996291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2070
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