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Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy
Cancer stem cells represent a novel therapeutic target. The major challenge in targeting leukemic stem cells (LSCs) is finding therapies that largely spare normal hematopoietic stems cells (HSCs) while eradicating quiescent LSCs. We present a mathematical model to predict how selective a therapy mus...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844253/ https://ncbi.nlm.nih.gov/pubmed/19996291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2070 |
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