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Targeting of cancer stem cells by differentiation therapy

Chemoresistance is a hallmark of cancer stem cells (CSCs). To develop novel therapeutic strategies that target CSCs, we established osteosarcoma‐initiating (OSi) cells by introducing the c‐Myc gene into bone marrow stromal cells derived from Ink4a/Arf KO mice. These OSi cells include bipotent commit...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Arima, Yoshimi, Nobusue, Hiroyuki, Saya, Hideyuki
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419023/
https://ncbi.nlm.nih.gov/pubmed/32462706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14504
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