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p66(shc) Inhibits Insulin-like Growth Factor-I Signaling via Direct Binding to Src through Its Polyproline and Src Homology 2 Domains, Resulting in Impairment of Src Kinase Activation

p66(shc) is increased in response to cell stress, and these increases regulate growth factor actions. These studies were conducted to determine how p66(shc) alters IGF-I-stimulated Src activation, leading to decreased IGF-I actions. Our results show that p66(shc) binds to Src through a polyproline s...

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Détails bibliographiques
Auteurs principaux: Xi, Gang, Shen, Xinchun, Clemmons, David R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844143/
https://ncbi.nlm.nih.gov/pubmed/20048152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069872
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