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PDK1 Recruitment to the SHPS-1 Signaling Complex Enhances Insulin-like Growth Factor-I-stimulated AKT Activation and Vascular Smooth Muscle Cell Survival

In vascular smooth muscle cells, exposed to hyperglycemia and insulin-like growth factor-I (IGF-I), SHPS-1 functions as a scaffold protein, and a signaling complex is assembled that leads to AKT activation. However, the underlying mechanism by which formation of this complex activates the kinase tha...

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Bibliografiska uppgifter
Huvudupphovsmän: Shen, Xinchun, Xi, Gang, Radhakrishnan, Yashwanth, Clemmons, David R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937974/
https://ncbi.nlm.nih.gov/pubmed/20643654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155325
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