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Hyperglycemia-Induced p66shc Inhibits Insulin-Like Growth Factor I-Dependent Cell Survival via Impairment of Src Kinase-Mediated Phosphoinositide-3 Kinase/AKT Activation in Vascular Smooth Muscle Cells

Hyperglycemia has been shown to induce the p66shc expression leading to increased reactive oxygen species (ROS) generation and apoptosis. In the present study, we demonstrated that hyperglycemia induced p66shc expression in vascular smooth muscle cells. This induction was associated with an increase...

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Bibliografiset tiedot
Päätekijät: Xi, Gang, Shen, Xinchun, Radhakrishnan, Yashwanth, Maile, Laura, Clemmons, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Endocrine Society 2010
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940520/
https://ncbi.nlm.nih.gov/pubmed/20534722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0242
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