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Insulin-like Growth Factor-I Stimulates Shc-dependent Phosphatidylinositol 3-Kinase Activation via Grb2-associated p85 in Vascular Smooth Muscle Cells

Insulin-like growth factor-I (IGF-I) stimulates vascular smooth muscle cell proliferation and migration by activating both MAPK and phosphatidylinositol 3-kinase (PI3K). Vascular smooth muscle cells (VSMCs) maintained in 25 mm glucose sustain MAPK activation via increased Shc phosphorylation and Grb...

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Библиографические подробности
Главные авторы: Radhakrishnan, Yashwanth, Maile, Laura A., Ling, Yan, Graves, Lee M., Clemmons, David R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423238/
https://ncbi.nlm.nih.gov/pubmed/18420583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801687200
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