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Insulin-like Growth Factor-I-stimulated Insulin Receptor Substrate-1 Negatively Regulates Src Homology 2 Domain-containing Protein-tyrosine Phosphatase Substrate-1 Function in Vascular Smooth Muscle Cells

Vascular smooth muscle cells maintained in normal (5.6 mm) glucose respond to insulin-like growth factor-I (IGF-I) with increased protein synthesis but do not proliferate. In contrast, hyperglycemia alters responsiveness to IGF-I, resulting in increased SHPS-1 phosphorylation and assembly of a signa...

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Auteurs principaux: Radhakrishnan, Yashwanth, Busby, Walker H., Shen, Xinchun, Maile, Laura A., Clemmons, David R.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871434/
https://ncbi.nlm.nih.gov/pubmed/20207740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092270
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