Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase.

Several substituted analogs of 7-(cis-3,5-dimethylpiperazinyl)-6,8-difluoro-5-amino-1-cyclopropyl quinolone were prepared and tested in a DNA cleavage assay with calf thymus topoisomerase II. Positioning of the methyl groups on the C-7 piperazine ring influenced potency against the mammalian enzyme;...

Descrición completa

Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Gootz, T D, McGuirk, P R, Moynihan, M S, Haskell, S L
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284408/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8141566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.1.130
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!