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Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase.

Several substituted analogs of 7-(cis-3,5-dimethylpiperazinyl)-6,8-difluoro-5-amino-1-cyclopropyl quinolone were prepared and tested in a DNA cleavage assay with calf thymus topoisomerase II. Positioning of the methyl groups on the C-7 piperazine ring influenced potency against the mammalian enzyme;...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Gootz, T D, McGuirk, P R, Moynihan, M S, Haskell, S L
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284408/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8141566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.1.130
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