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Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents.

Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays. The antitumor agents VP-16 (demethylepipodophyllotoxin ethylio-beta-D-glucoside) and e...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Barrett, J F, Gootz, T D, McGuirk, P R, Farrell, C A, Sokolowski, S A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1989
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC172740/
https://ncbi.nlm.nih.gov/pubmed/2556075
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