Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents.

Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays. The antitumor agents VP-16 (demethylepipodophyllotoxin ethylio-beta-D-glucoside) and e...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Barrett, J F, Gootz, T D, McGuirk, P R, Farrell, C A, Sokolowski, S A
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.10.1697
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