Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents.

Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays. The antitumor agents VP-16 (demethylepipodophyllotoxin ethylio-beta-D-glucoside) and e...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Barrett, J F, Gootz, T D, McGuirk, P R, Farrell, C A, Sokolowski, S A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.10.1697
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