Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group.

A previous study (M.J. Robinson, B.A. Martin, T.D. Gootz, P.R. McGuirk, M. Moynihan, J.A. Sutcliffe, and N. Osheroff, J. Biol. Chem. 266:14585-14592, 1991) demonstrated that novel 6,8-difluoroquinolones were potent effectors of eukaryotic topoisomerase II. To determine the contribution of the C-8 fl...

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Autores principales: Robinson, M J, Martin, B A, Gootz, T D, McGuirk, P R, Osheroff, N
Formato: Artigo
Lenguaje:Inglês
Publicado: 1992
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC189387/
https://ncbi.nlm.nih.gov/pubmed/1323952
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