Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly active against topoisomerase II in vitro and in mammalian cells in culture (M. J. Robinson, B. A. Martin, T. D. Gootz, P. R. McGuirk, M. Moynihan, J. A. Sutcliffe, and N. O...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Elsea, S H, McGuirk, P R, Gootz, T D, Moynihan, M, Osheroff, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192247/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2179
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