Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly active against topoisomerase II in vitro and in mammalian cells in culture (M. J. Robinson, B. A. Martin, T. D. Gootz, P. R. McGuirk, M. Moynihan, J. A. Sutcliffe, and N. O...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Elsea, S H, McGuirk, P R, Gootz, T D, Moynihan, M, Osheroff, N
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1993
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192247/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2179
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!