Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly active against topoisomerase II in vitro and in mammalian cells in culture (M. J. Robinson, B. A. Martin, T. D. Gootz, P. R. McGuirk, M. Moynihan, J. A. Sutcliffe, and N. O...

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出版年:	Antimicrob Agents Chemother
主要な著者:	Elsea, S H, McGuirk, P R, Gootz, T D, Moynihan, M, Osheroff, N
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1993
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192247/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2179
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Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

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