Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly active against topoisomerase II in vitro and in mammalian cells in culture (M. J. Robinson, B. A. Martin, T. D. Gootz, P. R. McGuirk, M. Moynihan, J. A. Sutcliffe, and N. O...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Elsea, S H, McGuirk, P R, Gootz, T D, Moynihan, M, Osheroff, N
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1993
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192247/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2179
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