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Structure-Activity Relationship of New Antituberculosis Agents Derived from Oxazoline and Oxazole Esters
During the syntheses and studies of natural iron chelators (mycobactins), we serendipitously discovered that a simple, small molecule, oxazoline-containing intermediate 3 displayed surprising anti-tuberculosis activity (MIC of 7.7 µM, average). Herein we report elaboration of SAR around this hit as...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843756/ https://ncbi.nlm.nih.gov/pubmed/20116900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.12.074 |
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