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Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels Alder reaction

Several novel oxazolidinone antibiotics with a spiropiperazinyl substituent at the 4’-position of the phenyl ring were synthesized through nitroso Diels–Alder chemistry and the in vitro antibacterial activities were evaluated against various Gram-positive bacteria (Bacillus subtilis, Staphylococcus...

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Detalhes bibliográficos
Main Authors: Ji, Cheng, Lin, Weimin, Moraski, Garrett C., Thanassi, Jane A., Pucci, Michael J., Franzblau, Scott G., Möllmann, Ute, Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363956/
https://ncbi.nlm.nih.gov/pubmed/22560837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.026
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