Inhibition of Lung Fluid Clearance and Epithelial Na(+) Channels by Chlorine, Hypochlorous Acid, and Chloramines

We investigated the mechanisms by which chlorine (Cl(2)) and its reactive byproducts inhibit Na(+)-dependent alveolar fluid clearance (AFC) in vivo and the activity of amiloride-sensitive epithelial Na(+) channels (ENaC) by measuring AFC in mice exposed to Cl(2) (0–500 ppm for 30 min) and Na(+) and...

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Autors principals: Song, Weifeng, Wei, Shipeng, Zhou, Yongjian, Lazrak, Ahmed, Liu, Gang, Londino, James D., Squadrito, Giuseppe L., Matalon, Sadis
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843221/
https://ncbi.nlm.nih.gov/pubmed/20106988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073981
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