Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

The mechanisms by which replicating influenza viruses decrease the expression and function of amiloride-sensitive epithelial sodium channels (ENaCs) have not been elucidated. We show that expression of M2, a transmembrane influenza protein, decreases ENaC membrane levels and amiloride-sensitive curr...

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Bibliographic Details
Main Authors: Lazrak, Ahmed, Iles, Karen E., Liu, Gang, Noah, Diana L., Noah, James W., Matalon, Sadis
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2009
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775009/
https://ncbi.nlm.nih.gov/pubmed/19596899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-135590
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