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Stereospecific Synthesis of Conformationally Constrained γ-Amino Acids: New Foldamer Building Blocks that Support Helical Secondary Struture

A highly stereoselective synthesis of novel cyclically constrained γ-amino acid residues is presented. The key step involves organocatalytic Michael addition of an aldehyde to 1-nitrocyclohexene. After aldehyde reduction, this approach provides optically active β-substituted-δ-nitro alcohols (96–99%...

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Detalhes bibliográficos
Main Authors: Guo, Li, Chi, Yonggui, Almeida, Aaron M., Guzei, Ilia A., Parker, Brian K., Gellman, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843141/
https://ncbi.nlm.nih.gov/pubmed/19886693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907233q
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