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Impact of γ-Amino Acid Residue Preorganization on α/γ-Peptide Foldamer Helicity in Aqueous Solution

α/γ-Peptide foldamers containing either γ(4)-amino acid residues or ring-constrained γ-amino acid residues have been reported to adopt 12-helical secondary structure in nonpolar solvents and in the solid state. These observations have engendered speculation that the seemingly flexible γ(4) residues...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Fisher, Brian F., Gellman, Samuel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972013/
https://ncbi.nlm.nih.gov/pubmed/27529788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06177
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