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Differential Impact of β and γ Residue Preorganization on α/β/γ-Peptide Helix Stability in Water

Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ resi...

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Détails bibliographiques
Auteurs principaux: Shin, Young-Hee, Mortenson, David E., Satyshur, Kenneth A., Forest, Katrina T., Gellman, Samuel H.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815483/
https://ncbi.nlm.nih.gov/pubmed/23701135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403319q
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