The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1

Existing long α-helix mimicking necessitates the retention of most natural amino acid residues to maintain their biological activity. Here, we report the exploration of helical sulfono-γ-AApeptides with entire unnatural backbones for their ability to structurally and functionally mimic glucagon-like...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Sang, Peng, Zhou, Zhihong, Shi, Yan, Lee, Candy, Amso, Zaid, Huang, David, Odom, Timothy, Nguyen-Tran, Vân T.B., Shen, Weijun, Cai, Jianfeng
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228743/
https://ncbi.nlm.nih.gov/pubmed/32440547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4988
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