G protein subunit Gα(13) binds to integrin α(IIb)β(3) and mediates integrin “outside-in” signaling

Integrins mediate cell adhesion to the extracellular matrix and transmit signals within the cell that stimulate cell spreading, retraction, migration, and proliferation. The mechanism of integrin outside-in signaling has been unclear. We found that the heterotrimeric guanine nucleotide-binding prote...

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Bibliografiske detaljer
Main Authors: Gong, Haixia, Shen, Bo, Flevaris, Panagiotis, Chow, Christina, Lam, Stephen C.-T., Voyno-Yasenetskaya, Tatyana A., Kozasa, Tohru, Du, Xiaoping
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842917/
https://ncbi.nlm.nih.gov/pubmed/20075254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1174779
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