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Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C

Dysregulation of NF-κB activity contributes to many autoimmune and inflammatory diseases. At least nine pathways for NF-κB activation have been identified, most of which converge on the IκB kinases (IKKs). Although IKKs represent logical targets for potential drug discovery, chemical inhibitors of I...

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Bibliografske podrobnosti
Main Authors:	Shi, Ranxin, Re, Daniel, Dudl, Eric, Cuddy, Michael, Okolotowicz, Karl J, Dahl, Russell, Su, Ying, Hurder, Andrew, Kitada, Shinichi, Peddibhotla, Satyamaheshwar, Roth, Gregory P., Smith, Layton H., Kipps, Thomas J., Cosford, Nicholas, Cashman, John, Reed, John C
Format:	Artigo
Jezik:	Inglês
Izdano:	2010
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2842467/ https://ncbi.nlm.nih.gov/pubmed/20141195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb9003089
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Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C

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