Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C

Dysregulation of NF-κB activity contributes to many autoimmune and inflammatory diseases. At least nine pathways for NF-κB activation have been identified, most of which converge on the IκB kinases (IKKs). Although IKKs represent logical targets for potential drug discovery, chemical inhibitors of I...

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Detalhes bibliográficos
Main Authors: Shi, Ranxin, Re, Daniel, Dudl, Eric, Cuddy, Michael, Okolotowicz, Karl J, Dahl, Russell, Su, Ying, Hurder, Andrew, Kitada, Shinichi, Peddibhotla, Satyamaheshwar, Roth, Gregory P., Smith, Layton H., Kipps, Thomas J., Cosford, Nicholas, Cashman, John, Reed, John C
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842467/
https://ncbi.nlm.nih.gov/pubmed/20141195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb9003089
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