Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules

[Image: see text] A unique series of biologically active chemical probes that selectively inhibit NF-κB activation induced by protein kinase C (PKC) pathway activators have been identified through a cell-based phenotypic reporter gene assay. These 2-aminobenzimidazoles represent initial chemical too...

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Autori principali: Peddibhotla, Satyamaheshwar, Shi, Ranxin, Khan, Pasha, Smith, Layton H., Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Okolotowicz, Karl J., Cashman, John R., Reed, John C., Roth, Gregory P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887059/
https://ncbi.nlm.nih.gov/pubmed/20481485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1000248
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