Imidazole - Derived Agonists for the Neurotensin 1 Receptor

A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound 1 showed full agonist behavior (79 – 93%) with an EC(50) of 2.0 – 4.1 μM a...

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Main Authors: Hershberger, Paul M., Hedrick, Michael P., Peddibhotla, Satyamaheshwar, Mangravita-Novo, Arianna, Gosalia, Palak, Li, Yujie, Gray, Wilson, Vicchiarelli, Michael, Smith, Layton H., Chung, Thomas D. Y., Thomas, James B., Caron, Marc G., Pinkerton, Anthony B., Barak, Lawrence S., Roth, Gregory P.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898338/
https://ncbi.nlm.nih.gov/pubmed/24332089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.026
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