IMMUNOSUPPRESSANT NEUROTOXICITY IN RAT BRAIN MODELS: OXIDATIVE STRESS AND CELLULAR METABOLISM

Co-administration of the calcineurin inhibitor cyclosporine (CsA) and the mTOR inhibitors sirolimus (SRL) or everolimus (RAD) increases efficacy of immunosuppression after organ transplantation. Neurotoxicity of CsA is a major clinical problem. Our goal was to assess the effects of CsA, SRL and RAD...

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Main Authors: Klawitter, Jelena, Gottschalk, Sven, Hainz, Carsten, Leibfritz, Dieter, Christians, Uwe, Serkova, Natalie J.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841482/
https://ncbi.nlm.nih.gov/pubmed/20148532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900351q
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