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IMMUNOSUPPRESSANT NEUROTOXICITY IN RAT BRAIN MODELS: OXIDATIVE STRESS AND CELLULAR METABOLISM
Co-administration of the calcineurin inhibitor cyclosporine (CsA) and the mTOR inhibitors sirolimus (SRL) or everolimus (RAD) increases efficacy of immunosuppression after organ transplantation. Neurotoxicity of CsA is a major clinical problem. Our goal was to assess the effects of CsA, SRL and RAD...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841482/ https://ncbi.nlm.nih.gov/pubmed/20148532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900351q |
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