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Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors

1. Co-administration of the calcineurin inhibitor cyclosporine and the mTOR inhibitors sirolimus or everolimus increases the efficacy of immunosuppression after organ transplantation. However, clinical studies showed enhancement of cyclosporine toxicity. To characterize the biochemical mechanisms in...

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Detalhes bibliográficos
Main Authors: Christians, Uwe, Gottschalk, Sven, Miljus, Jelena, Hainz, Carsten, Benet, Leslie Z, Leibfritz, Dieter, Serkova, Natalie
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575349/
https://ncbi.nlm.nih.gov/pubmed/15339861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705939
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