Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain

1. Clinical studies have shown enhancement of cyclosporine toxicity when co-administered with the immunosuppressant sirolimus. We evaluated the biochemical mechanisms underlying the sirolimus/cyclosporine interaction on rat brain metabolism using magnetic resonance spectroscopy (MRS) and compared th...

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Bibliografiske detaljer
Main Authors: Serkova, Natalie, Jacobsen, Wolfgang, Niemann, Claus U, Litt, Lawrence, Benet, Leslie Z, Leibfritz, Dieter, Christians, Uwe
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572850/
https://ncbi.nlm.nih.gov/pubmed/11454661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704142
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