Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain

1. Clinical studies have shown enhancement of cyclosporine toxicity when co-administered with the immunosuppressant sirolimus. We evaluated the biochemical mechanisms underlying the sirolimus/cyclosporine interaction on rat brain metabolism using magnetic resonance spectroscopy (MRS) and compared th...

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Hlavní autoři: Serkova, Natalie, Jacobsen, Wolfgang, Niemann, Claus U, Litt, Lawrence, Benet, Leslie Z, Leibfritz, Dieter, Christians, Uwe
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572850/
https://ncbi.nlm.nih.gov/pubmed/11454661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704142
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