Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice

We hypothesize that regulatory T-cell (Treg)-deficient strains have an altered TCR repertoire in part due to the expansion of autoimmune repertoire by self-antigen. We compared the Vβ family expression profile between B6 and Treg-lacking B6.Cg-Foxp3(sf)(/Y) (B6.sf) mice using fluorescent anti-Vβ mAb...

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Main Authors: Zheng, Lingjie, Sharma, Rahul, Kung, John T., Deshmukh, Umesh S., Jarjour, Wael N., Fu, Shu Man, Ju, Shyr-Te
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841480/
https://ncbi.nlm.nih.gov/pubmed/18310063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn017
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