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X-linked Foxp3 (Sf) Mutation Dominantly Inhibits Submandibular Gland Development and Inflammation Respectively through Adaptive and Innate Immune Mechanisms
Scurfy (Foxp3(Sf)/Y), Il2(-/-) and Il2rα(-/-) mice are deficient in CD4(+)Foxp3(+) regulatory T cells (Treg) but only the latter two develop inflammation in the submandibular gland (SMG), a critical target of Sjögren's syndrome. Here, we investigated the reason why SMG of Sf, Sf.Il2(-/-), Sf.Il...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735024/ https://ncbi.nlm.nih.gov/pubmed/19648271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804355 |
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