Chaperone-supervised conversion of prion protein to its protease-resistant form

Transmissible spongiform encephalopathies (TSEs) are lethal, infectious disorders of the mammalian nervous system. A TSE hallmark is the conversion of the cellular protein PrP(C) to disease-associated PrP(Sc) (named for scrapie, the first known TSE). PrP(C) is protease-sensitive, monomeric, detergen...

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Main Authors: DebBurman, Shubhik K., Raymond, Gregory J., Caughey, Byron, Lindquist, Susan
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences of the USA 1997
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC28411/
https://ncbi.nlm.nih.gov/pubmed/9391131
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