Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin

Inhibition of the accumulation of protease-resistant prion protein (PrP-res) is a prime strategy in the development of potential transmissible spongiform encephalopathy (TSE) therapeutics. Here we show that curcumin (diferoylmethane), a major component of the spice turmeric, potently inhibits PrP-re...

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Main Authors: Caughey, Byron, Raymond, Lynne D., Raymond, Gregory J., Maxson, Laura, Silveira, Jay, Baron, Gerald S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC153975/
https://ncbi.nlm.nih.gov/pubmed/12692251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.9.5499-5502.2003
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