Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin

Inhibition of the accumulation of protease-resistant prion protein (PrP-res) is a prime strategy in the development of potential transmissible spongiform encephalopathy (TSE) therapeutics. Here we show that curcumin (diferoylmethane), a major component of the spice turmeric, potently inhibits PrP-re...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Caughey, Byron, Raymond, Lynne D., Raymond, Gregory J., Maxson, Laura, Silveira, Jay, Baron, Gerald S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Vaccines and Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12692251/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.9.5499-5502.2003
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