Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and ou...

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Detalles Bibliográficos
Autores principales: Laursen, Nick S., Gordon, Natasha, Hermans, Stefan, Lorenz, Natalie, Jackson, Nicola, Wines, Bruce, Spillner, Edzard, Christensen, Jesper B., Jensen, Morten, Fredslund, Folmer, Bjerre, Mette, Sottrup-Jensen, Lars, Fraser, John D., Andersen, Gregers R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840425/
https://ncbi.nlm.nih.gov/pubmed/20133685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910565107
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