Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and ou...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Laursen, Nick S., Gordon, Natasha, Hermans, Stefan, Lorenz, Natalie, Jackson, Nicola, Wines, Bruce, Spillner, Edzard, Christensen, Jesper B., Jensen, Morten, Fredslund, Folmer, Bjerre, Mette, Sottrup-Jensen, Lars, Fraser, John D., Andersen, Gregers R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840425/
https://ncbi.nlm.nih.gov/pubmed/20133685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910565107
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