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Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and ou...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840425/ https://ncbi.nlm.nih.gov/pubmed/20133685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910565107 |
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