Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and ou...

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Hlavní autoři: Laursen, Nick S., Gordon, Natasha, Hermans, Stefan, Lorenz, Natalie, Jackson, Nicola, Wines, Bruce, Spillner, Edzard, Christensen, Jesper B., Jensen, Morten, Fredslund, Folmer, Bjerre, Mette, Sottrup-Jensen, Lars, Fraser, John D., Andersen, Gregers R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840425/
https://ncbi.nlm.nih.gov/pubmed/20133685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910565107
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