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Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability
Theoretical analyses suggest that the cellular internalization and catabolism of bound antibodies contribute significantly to poor penetration into tumors. Here we quantitatively assess the internalization of antibodies and antibody fragments against the commonly targeted antigen carcinoembryonic an...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840397/ https://ncbi.nlm.nih.gov/pubmed/18408925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0518-1 |
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