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Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

Theoretical analyses suggest that the cellular internalization and catabolism of bound antibodies contribute significantly to poor penetration into tumors. Here we quantitatively assess the internalization of antibodies and antibody fragments against the commonly targeted antigen carcinoembryonic an...

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Detalhes bibliográficos
Main Authors: Schmidt, Michael M., Thurber, Greg M., Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840397/
https://ncbi.nlm.nih.gov/pubmed/18408925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0518-1
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