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Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

Theoretical analyses suggest that the cellular internalization and catabolism of bound antibodies contribute significantly to poor penetration into tumors. Here we quantitatively assess the internalization of antibodies and antibody fragments against the commonly targeted antigen carcinoembryonic an...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Schmidt, Michael M., Thurber, Greg M., Wittrup, K. Dane
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840397/
https://ncbi.nlm.nih.gov/pubmed/18408925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0518-1
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